Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation
Tobias Wagener, Arne Heusler, Zackaria Nairoukh, Klaus Bergander, Constantin G. Daniliuc, Frank Glorius
Abstract
-selective hydrogenation of abundant and cheap fluoropyridines to yield a broad scope of (multi)fluorinated piperidines. This protocol enables the chemoselective reduction of fluoropyridines while tolerating other (hetero)aromatic systems using a commercially available heterogenous catalyst. Fluorinated derivatives of important drug compounds are prepared, and a straightforward strategy for the synthesis of enantioenriched fluorinated piperidines is disclosed.
Topics & Concepts
Combinatorial chemistryCatalysisYield (engineering)ChemistryAgrochemicalOrganic chemistryScope (computer science)Computer scienceMaterials scienceProgramming languageEcologyAgricultureMetallurgyBiologyFluorine in Organic ChemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis