FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
Yingyi Zhang, Jielu Hao, Mariana G. Tarragó, Gina M. Warner, Nino Giorgadze, Qing Wei, Yan Huang, Kai He, Chuan Chen, Thais Peclat, Thomas A. White, Kun Ling, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini, Jinghua Hu
Abstract
mice further fed a high-fat diet are protected from diabetes and premature death. We reveal a central role for primary cilia in the fate determination of preadipocytes and the generation of metabolically healthy fat tissue.
Topics & Concepts
AdipogenesisCiliumAdipose tissueWhite adipose tissueCell biologyBiologyEndocrinologyHedgehog signaling pathwayInternal medicineBrown adipose tissueSignal transductionMedicineGenetic and Kidney Cyst DiseasesFibroblast Growth Factor ResearchLipid metabolism and biosynthesis