Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis
Ruping Sun, Jian Zhu, Kaiqiang Sun, Lu Gao, Bing Zheng, Jiangang Shi
Abstract
therapeutic effect of SRR on IVDD was confirmed. Our findings may contribute to the understanding of the complex interplay between inflammation and degenerative processes in the intervertebral disc and provide valuable insights into the development of targeted treatment-based therapeutics for IVDD.
Topics & Concepts
Strontium ranelateIntervertebral discInflammationGene knockdownTransforming growth factorCell biologyNF-κBCancer researchOxidative stressSignal transductionNucleusIn vivoIn vitroMedicineChemistryCell cultureBiologyPathologyImmunologyOsteoporosisInternal medicineAnatomyBiochemistryGeneticsSpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationPregnancy-related medical research