Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity
Lin Wu, Yingmei Zhang, Guizhen Wang, Jun Ren
Abstract
Ferroptosis, an iron-dependent form of regulated cell death, has received increasing attention for its pathophysiologic contribution to the onset and development of doxorubicin-induced cardiotoxicity. Moreover, modulation of ferroptosis with specific inhibitors may provide new therapeutic opportunities for doxorubicin-induced cardiotoxicity. Here, we will review the molecular mechanisms and therapeutic promise of targeting ferroptosis in doxorubicin-induced cardiotoxicity.
Topics & Concepts
CardiotoxicityDoxorubicinMedicinePharmacologyProgrammed cell deathCancer researchChemotherapyApoptosisChemistryInternal medicineBiochemistryFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer