Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021
Basil Britto Xavier, Jasmine Coppens, Sien De Koster, Sahaya Glingston Rajakani, Sam Van Goethem, Samy Mzougui, Ahalieyah Anantharajah, Christine Lammens, Katherine Loens, Y. Glupczynski, Herman Goossens, Veerle Matheeussen
Abstract
We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP , was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridium scidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.
Topics & Concepts
Enterococcus faeciumVancomycinOperonGene clusterMicrobiologyBiologyGeneGeneticsEnterococcusHorizontal gene transferMinimum inhibitory concentrationAntibioticsGenomeBacteriaStaphylococcus aureusEscherichia coliAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingClostridium difficile and Clostridium perfringens research