Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane
Mahama Alhassan, Othman Al Musaimi, Jonathan M. Collins, Fernando Alberício, Beatriz G. de la Torre
Abstract
Anisole and 1,3-dimethoybenzene are excellent alternatives to DCM for cleaving protected peptides.
Topics & Concepts
DichloromethaneChemistryChlorideOrganic chemistrySolventChemical Synthesis and ReactionsChemistry and Chemical EngineeringChemical Synthesis and Analysis