Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations
Carina Glas, Johannes C. B. Dietschreit, Nathalie Wössner, Lars Urban, Ehab Ghazy, Wolfgang Sippl, Manfred Jung, Christian Ochsenfeld, Franz Bracher
Topics & Concepts
ChemistryPotencyStereochemistryDocking (animal)NAD+ kinaseBiochemistryLead compoundEnzymeIn vitroNursingMedicineSirtuins and Resveratrol in MedicinePARP inhibition in cancer therapyCalcium signaling and nucleotide metabolism