Bimetallic nanoconjugate hijack Fe-S clusters to drive a closed-loop cuproptosis-ferroptosis strategy for osteosarcoma inhibition
Guanhong Liu, Rongze Tang, Congcong Wang, Dehong Yu, Zhenxin Wang, Haochen Yang, Jia Wei, Shunhua Zhu, Fenglei Gao, Yuan Feng, Bin Pan
Topics & Concepts
ChemistryOsteosarcomaReactive oxygen speciesMitochondrionCell biologyIn vivoBimetallic stripHyaluronic acidOxidative stressGlutathioneBiochemistryBiophysicsBioenergeticsCancer researchOxidative phosphorylationAcetyltransferaseIn vitroLipid peroxidationPhosphataseOxygenAcetylationCancer cellCardiolipinToxicityDisulfiramTumor microenvironmentMetabolismMicroRNA in disease regulationFerroptosis and cancer prognosisRNA modifications and cancer