Deletion of Kir5.1 abolishes the effect of high Na<sup>+</sup> intake on Kir4.1 and Na<sup>+</sup>-Cl<sup>−</sup> cotransporter
Xin‐Peng Duan, Peng Wu, Dandan Zhang, Zhong‐Xiuzi Gao, Yu Xiao, Evan C. Ray, Wen‐Hui Wang, Dao‐Hong Lin
Abstract
Kir5.1 plays an important role in mediating the effect of high sodium intake on basolateral K + channels in the distal convoluted tubule and Na + -Cl − cotransporter activity/expression.
Topics & Concepts
ChemistryCotransporterDistal convoluted tubuleEndocrinologyInternal medicineSymporterExcretionRenal physiologyKidneyNatriuresisReabsorptionSodiumRenal functionTransporterBiochemistryBiologyMedicineOrganic chemistryGeneIon Transport and Channel RegulationElectrolyte and hormonal disordersMagnesium in Health and Disease