The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na<sub>V</sub>1.7 via the Ubiquitin-Ligase NEDD4-2
Alexandru‐Florian Deftu, Paul Chu Sin Chung, Cedric Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Décosterd
Abstract
mice, suggesting that metformin can also change neuronal excitability in an NEDD4-2-independent manner. We suggest that NEDD4-2 is a critical player for the effect of metformin on the excitability of nociceptive neurons; this action may contribute to the relief of neuropathic pain.
Topics & Concepts
MetforminPharmacologyPatch clampEndocrinologyDorsal root ganglionChemistryInternal medicineMedicineElectrophysiologyAnatomyDiabetes mellitusDorsumPain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchMetabolism, Diabetes, and Cancer