Inhibiting PP2Ac<i>α</i> Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
Zhaoxiang Cheng, Shan Gao, Xiaojie Liang, Chao Lian, Jianquan Chen, Chao Fang
Abstract
This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit C α (PP2Ac α , encoded by PPP2CA ) and methyltransferase‐like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochemistry results, we found that abnormal PP2Ac α and METTL3 levels were closely related to the malignant progression of GC. To explore the internal connection between PP2Ac α and METTL3 in the progression of GC, we carried out cellular and molecular experiments and finally proved that PP2Ac α inhibition can upregulate METTL3 levels by activating ATM activity, thereby promoting the malignant progression of GC.