An impedimetric sensor based on molecularly imprinted nanoparticles for the determination of trypsin in artificial matrices – towards point-of-care diagnostics
Sabrina Di Masi, Marco Costa, Francesco Canfarotta, António Guerreiro, A. M. Hartley, Sergey A. Piletsky, Cosimino Malitesta
Abstract
the response of imprinted polymers compared with the non-imprinted control). The developed sensor was tested towards a range of concentrations of trypsin dissolved in ammonium acetate (pH = 6) and showed promising applicability in artificial saliva, with a recovery percentage between 103 and 107%.
Topics & Concepts
Molecularly imprinted polymerTrypsinNanoparticleChemistryBiomarkerNanotechnologyChromatographyMaterials scienceBiochemistryEnzymeSelectivityCatalysisAnalytical chemistry methods developmentMass Spectrometry Techniques and ApplicationsPharmacological Effects and Assays