PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis
Xiaoyu Shen, Jiamei Zhang, Zhou Zhou, Rui-Qun Yu
Abstract
/MDA/ROS, and expression of interleukin (IL)-1β/IL-18/intranuclear P65 in PA-stimulated HL-1 cells. PIR silencing counteracted the roles of PLIN5 overexpression in PA-stimulated HL-1 cells.PLIN5 suppresses lipotoxicity and ferroptosis in cardiomyocyte via modulating PIR/NF-κB axis, hinting its potential as a therapeutic target in DCM.
Topics & Concepts
LipotoxicityMedicineNF-κBCell biologyCancer researchInternal medicineNFKB1EndocrinologyGeneTranscription factorBiochemistryInflammationInsulinBiologyChemistryInsulin resistanceFerroptosis and cancer prognosisCholesterol and Lipid MetabolismCaveolin-1 and cellular processes