A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells
Robert C. Peery, Qingbin Cui, Kwaku Kyei‐Baffour, Sophia Josephraj, Caoqinglong Huang, Zizheng Dong, Mingji Dai, Jian‐Ting Zhang, Jingyuan Liu
Topics & Concepts
SurvivinChemistryProdrugApoptosisCancer researchCancer cellInhibitor of apoptosisProstate cancerLinkerDocetaxelProteasome inhibitorBiochemistryPharmacologyCancerProgrammed cell deathInternal medicineBiologyMedicineComputer scienceOperating systemCell death mechanisms and regulationUbiquitin and proteasome pathwaysRNA Interference and Gene Delivery