The multifaceted role of the mineralocorticoid receptor in cancers
Tram B. Doan, J. Dinny Graham
Abstract
The mineralocorticoid receptor (MR/NR3C2) is a member of the family of steroid receptors (SR) which also includes the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and glucocorticoid receptor (GR). They function primarily as nuclear receptors to regulate gene expression. While the other steroid hormone receptors are known to play important roles in the pathogenesis and progression of many cancers, relatively little is understood about the role of MR in cancer biology. This review focuses on examining new insights into the potential roles and mechanisms of action of MR in cancers.
Topics & Concepts
Mineralocorticoid receptorReceptorNuclear receptorEstrogen receptorMineralocorticoidEstrogen-related receptor gammaGlucocorticoid receptorAndrogen receptorBiologySteroid hormoneEndocrinologySteroid hormone receptorEstrogen-related receptor alphaInternal medicineEstrogen receptor alphaHormoneGlucocorticoidCancerMedicineGeneTranscription factorProstate cancerGeneticsBreast cancerHormonal Regulation and HypertensionEstrogen and related hormone effectsPharmacogenetics and Drug Metabolism