An oxidatively damaged G-quadruplex/hemin DNAzyme
Jiawei Wang, Mingpan Cheng, Jielin Chen, Huangxian Ju, David Monchaud, Jean‐Louis Mergny, Jun Zhou
Abstract
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.
Topics & Concepts
DeoxyribozymeHeminG-quadruplexChemistryGuanineBiophysicsBiochemistryDNAHemeBiologyNucleotideEnzymeGeneAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery