Micro-total process system machine (μ-TPSM) for rapid synthesis of antiretroviral darunavir
Ruchi Chauhan, Abhilash Rana, Subhash Ghosh, Srihari Pabbaraja, Ajay K. Singh
Abstract
Herein, we have reported the μ-TPSM for the synthesis of Darunavir within 41 min of total residence time with a 71% isolated yield, and an output of 0.8 g h −1 .
Topics & Concepts
DarunavirHuman immunodeficiency virus (HIV)Yield (engineering)ChemistryMedicineAntiretroviral therapyVirologyMaterials scienceViral loadMetallurgyInnovative Microfluidic and Catalytic Techniques InnovationNanomaterials for catalytic reactionsAdvanced biosensing and bioanalysis techniques