Asymmetric synthesis of syn-aryl-(2S,3R)-2-chloro-3-hydroxy esters via an engineered ketoreductase-catalyzed dynamic reductive kinetic resolution
Xiaoping Yue, Yitong Li, Di Sang, Yuan Tao, Zedu Huang, Fen‐Er Chen
Topics & Concepts
Kinetic resolutionArylChemistrySubstrate (aquarium)CatalysisCombinatorial chemistryReductive eliminationFunction (biology)StereochemistryEnantioselective synthesisOrganic chemistryBiologyAlkylEcologyEvolutionary biologyEnzyme Catalysis and ImmobilizationSynthesis and Catalytic ReactionsCarbohydrate Chemistry and Synthesis