Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF<sup>V600E</sup> inhibitors
Lamya H. Al-Wahaibi, Bahaa G. M. Youssif, Hesham A. Abou‐Zied, Stefan Bräse, Alan B. Brown, Hendawy N. Tawfeek, Essmat M. El‐Sheref
Abstract
A series of new pyrazolylquinolin-2-ones were designed and synthesised. The structures of the new compounds were validated by IR, NMR, and elemental analysis. The new compounds were evaluated as antiproliferative agents targeting EGFR and BRAF V600E .
Topics & Concepts
ApoptosisSeries (stratigraphy)ChemistryEGFR inhibitorsCancer researchDual (grammatical number)PharmacologyCombinatorial chemistryStereochemistryEpidermal growth factor receptorMedicineBiologyBiochemistryReceptorPaleontologyLiteratureArtComputational Drug Discovery MethodsMelanoma and MAPK PathwaysSynthesis and biological activity