Incidence of Cutaneous Reactions After Messenger RNA COVID-19 Vaccines
Lacey B. Robinson, Xiaoqing Fu, Dean M. Hashimoto, Paige G. Wickner, Erica S. Shenoy, Adam Landman, Kimberly G. Blumenthal
Abstract
matous inflammation that expressed CD163, consonant with an M2 macrophage phenotype. Although the dynamic spectrum of TAMs has not been clearly delineated, 3 this shifting macrophage profile across clinically distinct lesions in 2 patients underscores the fundamental role and plasticity of macrophages in the evolution of this eruption. We suspect that the critical role of macrophages and their associated cytokines in wound healing and scar formation 4 as well as the production of interleukin 34, one of 2 distinct ligands for colonystimulating factor 1 receptor, by keratinocytes and hair follicles may contribute to this pathogenesis. he striking near-complete normalization of lesions on cessation of therapy in 3 patients suggests a compensatory immunologic response that facilitated repair. Recapitulation of this phenomenon in other disease states (eg, connective tissue disease) has wide-reaching implications.