Rifabutin Is Inactivated by Mycobacterium abscessus Arr
Daniel Schäfle, Petra Selchow, Barbara Borer, Michael Meuli, Anna Rominski, Bettina Schulthess, Peter Sander
Abstract
Mycobacterium abscessus exhibits arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr.
Topics & Concepts
RifabutinMycobacterium abscessusMicrobiologyNontuberculous mycobacteriaMycobacteriumMedicineBiologyAntibioticsBacteriaClarithromycinGeneticsMycobacterium research and diagnosisTuberculosis Research and EpidemiologyClostridium difficile and Clostridium perfringens research