Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors
Minhao Huang, Yongjun Huang, Jing Guo, Lei Yu, Chang Yeon Yu, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang, Zhang Zhang, Ke Ding
Topics & Concepts
ChemistryBioavailabilityIC50PharmacologyPharmacokineticsTyrosine kinaseKinaseIn vivoGrowth inhibitionTyrosine-kinase inhibitorPaclitaxelThreonineCell growthPhosphorylationCancerCancer researchBiochemistryIn vitroInternal medicineSignal transductionMedicineSerineBiologyBiotechnologyBiochemical and Molecular ResearchChronic Lymphocytic Leukemia ResearchQuinazolinone synthesis and applications