Inflammation and hematopoietic stem cells aging
Hanqing He, Jianwei Wang
Abstract
Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and extrinsic factors have been identified to promote HSCs aging. In this review, we focus on the contribution of aging-associated inflammation in provoking HSCs aging and discuss the future research direction of inflammation and HSC aging.
Topics & Concepts
HaematopoiesisStem cellInflammationBiologyStem cell theory of agingHematopoietic stem cellCell biologyMyeloidImmunologySenescenceStem cell factorHematopoietic Stem Cell TransplantationImmune cells in cancerImmune Cell Function and Interaction