An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes
János P. Mészáros, Jelena M. Poljarević, István Szatmári, Oszkár Csuvik, Ferenc Fülöp, Norbert Szoboszlai, Gabriella Spengler, Éva A. Enyedy
Abstract
) complex were somewhat more effective against drug resistant Colo 320 adenocarcinoma human cells compared to the drug sensitive Colo 205 cells. The Ru- and Rh-complexes showed a similar metal uptake level after 4 h, while a longer incubation time resulted in higher cellular Rh concentration.
Topics & Concepts
8-HydroxyquinolineLipophilicityChemistryProlineOrganometallic chemistryAqueous solutionGroup 2 organometallic chemistryCombinatorial chemistryStereochemistryOrganic chemistryMoleculeAmino acidBiochemistryCatalysisMetal complexes synthesis and propertiesMolecular Sensors and Ion DetectionDNA and Nucleic Acid Chemistry