IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lü, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Şevin Turcan, Omar Abdel‐Wahab, Christopher R. Edwards, Raya Khanin, María E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O’Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff, Craig B. Thompson
Topics & Concepts
BiologyHistoneCellular differentiationHistone methylationDNA methylationDemethylaseMolecular biologyEpigeneticsH3K4me3Histone methyltransferaseMethylationCancer researchCell biologyGene expressionGeneticsGenePromoterEpigenetics and DNA MethylationGlioma Diagnosis and TreatmentHistone Deacetylase Inhibitors Research