Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design
Yu Chen, Fengyuan Liu, Samira Pal, Quanyin Hu
Abstract
applications of TPD strategies by reshaping their pharmacokinetics and pharmacodynamic profiles. These proteolysis-targeting drug delivery systems (ProDDSs) exhibit superior delivery performance, enhanced targetability, and reduced off-tissue side effects. In this review, we will survey the latest progress in TPD-inspired drug delivery systems, highlight the importance of introducing delivery ideas or technologies to the development of protein degraders, outline design principles of protein degrader-inspired delivery systems, discuss the current challenges, and provide an outlook on future opportunities in this field.
Topics & Concepts
ProteolysisDrug deliveryTargeted drug deliveryDrugComputer scienceComputational biologyNanotechnologyChemistryPharmacologyMedicineBiologyMaterials scienceBiochemistryEnzymeProtein Degradation and InhibitorsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques