Functional Role of microRNAs in Regulating Cardiomyocyte Death
Urna Kansakar, Fahimeh Varzideh, Pasquale Mone, Stanislovas S. Jankauskas, Gaetano Santulli
Abstract
microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.
Topics & Concepts
microRNAAngiogenesisAutophagyMyocardial infarctionInflammationProgrammed cell deathApoptosisIschemiaHeart failureDiseaseMedicineBiologyReperfusion injuryBioinformaticsCell biologyCancer researchImmunologyPathologyCardiologyGeneticsGeneAutophagy in Disease and TherapyMicroRNA in disease regulationCalpain Protease Function and Regulation