PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine
Chang‐Keun Cho, Pureum Kang, Choon‐Gon Jang, Seok‐Yong Lee, Yun Jeong Lee, Jung‐Woo Bae, Chang‐Ik Choi
Topics & Concepts
VenlafaxineCYP2D6ParoxetinePharmacologyPharmacokineticsDrugPhysiologically based pharmacokinetic modellingClarithromycinMetaboliteActive metaboliteMedicineChemistryGenotypeAntidepressantInternal medicineGeneBiochemistryHelicobacter pyloriHippocampusPharmacogenetics and Drug MetabolismInflammatory mediators and NSAID effectsAnalytical Chemistry and Chromatography