Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
Yanan Li, Wenjun Kong, Wei Yang, Riddhi Patel, Emily B. Casey, Theresa Okeyo-Owuor, J. Michael White, Shaina N. Porter, Samantha A. Morris, Jeffrey A. Magee
Topics & Concepts
BiologyProgenitor cellHaematopoiesisEnhancerStem cellHeterochronyReprogrammingTranscriptomeCell biologyLineage (genetic)OntogenyLymphopoiesisRegulation of gene expressionTransition (genetics)GeneHematopoietic stem cellFetusGene expressionGeneticsPregnancySingle-cell and spatial transcriptomicsHematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation