Accurate Correction of the “Bulk Response” in Surface Plasmon Resonance Sensing Provides New Insights on Interactions Involving Lysozyme and Poly(ethylene glycol)
Justas Svirelis, John Andersson, Anna Stradner, Andreas Dahlin
Abstract
< 30 s). Furthermore, we show that the bulk response correction also reveals the dynamics of self-interactions between lysozyme molecules on surfaces. Besides providing new insights on important biomolecular interactions, our method can be widely applied to improve the accuracy of SPR data generated by instruments worldwide.
Topics & Concepts
Surface plasmon resonanceLysozymeEthylene glycolPolymerMoleculeMaterials scienceBiosensorResonance (particle physics)Biological systemChemical physicsSurface (topology)NanotechnologyChemistryPhysicsNanoparticleOrganic chemistryAtomic physicsMathematicsBiologyBiochemistryComposite materialGeometryAdvanced biosensing and bioanalysis techniquesMonoclonal and Polyclonal Antibodies ResearchAdvanced Biosensing Techniques and Applications