ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling
Muhong Guo, Ge Ma, Xiaolan Zhang, Weiwei Tang, Junfeng Shi, Qian Wang, Ye Cheng, Bin Zhang, Jin Xu
Abstract
. In addition, our data revealed that ROR2 promotes proliferation of BC cells by activating the PI3K/AKT signaling pathway. Together, our results indicate that ROR2 acts as an oncogenic gene in breast cancer, and suggest that the ROR2/PI3K/AKT regulatory network contributes to breast cancer progression.
Topics & Concepts
Gene knockdownBreast cancerCancer researchPI3K/AKT/mTOR pathwayCancerSignal transductionMedicineBiologyInternal medicineCell biologyApoptosisGeneticsPI3K/AKT/mTOR signaling in cancerKruppel-like factors researchFOXO transcription factor regulation