Overall survival of pancreatic ductal adenocarcinoma is doubled by <i>Aldh7a1</i> deletion in the KPC mouse
Jae-Seon Lee, Ho Lee, Sang Myung Woo, Hyonchol Jang, Yoon Jeon, Hee Yeon Kim, Jaewhan Song, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park, Sung‐Sik Han, Soo‐Youl Kim
Abstract
Inhibitions of ALDH7A1 and oxidative phosphorylation using gossypol and phenformin resulted in a regression of tumor formation in xenograft mice model and KPC mice model.
Topics & Concepts
Cancer researchAldehyde dehydrogenaseLipid peroxidationChemistryBiologyMolecular biologyBiochemistryOxidative stressEnzymeCancer, Hypoxia, and MetabolismCancer, Lipids, and MetabolismPI3K/AKT/mTOR signaling in cancer