Utility of an <i>in vitro</i> lymphatics on-chip model for rank ordering subcutaneous absorption of monoclonal antibodies
Adriana M. Ledo, Gabriela Misiewicz, Thomas Dimke, William R. Tschantz, J. van den Handel, Ryan M. Pelis, Gerard Bruin, Karoline Bechtold-Peters, Manuel Sánchez-Félix, Sujal V. Deshmukh, Seunggyu Kim, Maria Proestaki, Roger D. Kamm
Abstract
= 0.8929). The on-chip lymphatics model described here appears as a promising tool for rank ordering subcutaneous lymphatic absorption during early drug development to increase the potential for successful candidate selection moving toward the clinic.
Topics & Concepts
MacromoleculeMonoclonal antibodyLymphatic systemIn vitroAbsorption (acoustics)Subcutaneous injectionAntibodyChemistryCell biologyBiologyImmunologyBiochemistryBioinformaticsMaterials scienceComposite materialMicrofluidic and Bio-sensing TechnologiesTransgenic Plants and Applications3D Printing in Biomedical Research