A comprehensive review and recent advances on isatin-based compounds as a versatile framework for anticancer therapeutics (2020–2025)
Muna A. Alshams, Mohamed S. Nafie, Heba F. Ashour, Asmaa S. A. Yassen
Abstract
, microwave-assisted and multi-component techniques, which offer improved pharmacological profiles of these isatin-heterocyclic hybrids with improved cytotoxicity and target signaling pathways. Overall, these results underscore the value of isatin as a flexible scaffold for the rational design of new anticancer agents. To increase bioavailability and targeted delivery, especially in solid tumors, and to lead to the creation of novel, potent anticancer therapies, nano-formulation drug delivery systems with revolutionary drug signaling pathways will be further advocated in the future.
Topics & Concepts
IsatinCytotoxicityAnticancer drugChemistryDrugRational designMechanism of actionDrug discoveryComputational biologyKinaseMechanism (biology)PharmacologyCancer cellSignal transductionNanotechnologyDrug designCancer treatmentLead compoundDrug developmentCombinatorial chemistryCancerApoptosisBiologyBioinformaticsClick Chemistry and ApplicationsSynthesis and biological activityCancer therapeutics and mechanisms