Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH<sub>4</sub>I-Promoted Three-Component Tandem Reaction
Fang Fang, Jie Xia, Siying Quan, Shanping Chen, Guo‐Jun Deng
Abstract
A facile and practical approach for the preparation of substituted pyrimidines from ketones, NH 4 OAc, and N, N -dimethylformamide dimethyl acetal has been described. This NH 4 I-promoted three-component tandem reaction affords a broad range of substituted pyrimidines in acceptable yields under metal- and solvent-free conditions. The present methodology features the advantages of simple and easily available starting materials, metal- and solvent-free conditions, a broad substrate scope with good functional group tolerance, and gram-scale synthesis.
Topics & Concepts
TandemChemistryDimethylformamideSolventComponent (thermodynamics)Cascade reactionCombinatorial chemistryFunctional groupMetalScope (computer science)Organic chemistryCatalysisMaterials scienceComputer sciencePolymerPhysicsThermodynamicsComposite materialProgramming languageMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applicationsChemical Synthesis and Analysis