A chemical biology approach reveals a dependency of glioblastoma on biotin distribution
Jeehyun Yoon, Oleg V. Grinchuk, Srinivasaraghavan Kannan, Melgious Jin Yan Ang, Zhenglin Li, Emmy Xue Yun Tay, Ker Zhing Lok, Bernice Woon Li Lee, You Heng Chuah, Kimberly Chia, Roberto Tirado-Magallanes, Chen‐Fei Liu, Haonan Zhao, Jin Hui Hor, Jhin Jieh Lim, Touati Benoukraf, Tan Boon Toh, Edward Kai‐Hua Chow, Jean‐Paul Kovalik, Jianhong Ching, Shi‐Yan Ng, Ming Joo Koh, Xiaogang Liu, Chandra Verma, Derrick Sek Tong Ong
Abstract
expression robustly indicates a poor prognosis. Thus, the dependency of GBM on biotin distribution suggests that the rational cotargeting of biotin-dependent metabolism and epigenetic pathways may be explored for GSC eradication.
Topics & Concepts
BiotinBiologyHistoneHistone H3TranscriptomeAcetylationEpigeneticsIntracellularCancer researchCell biologyGene expressionBiochemistryGeneBiotin and Related StudiesCellular transport and secretionProtein Degradation and Inhibitors