Base-catalysed <sup>18</sup>F-labelling of trifluoromethyl ketones. Application to the synthesis of <sup>18</sup>F-labelled neutrophil elastase inhibitors
Denise N. Meyer, Miguel A. Cortés González, Xingguo Jiang, Linus Johansson Holm, Monireh Pourghasemi Lati, Mathias Elgland, Patrik Nordeman, Gunnar Antoni, Kálmán J. Szabó
Abstract
functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.
Topics & Concepts
LabellingTrifluoromethylChemistryFluorineBase (topology)RadiochemistryMedicinal chemistryOrganic chemistryBiochemistryMathematicsMathematical analysisAlkylFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsChemical Synthesis and Analysis