Histological analysis of the gastrocnemius muscle in preschool and school age children with cerebral palsy compared with age-matched typically developing children
Jorieke Deschrevel, Anke Andries, Karen Maes, Jules Peeters, Axel van Opstal, Dina Jiang, Nathalie De Beukelaer, Marlies Corvelyn, Lauraine Staut, Hannah De Houwer, Domiziana Costamagna, Kaat Desloovere, Anja Van Campenhout, Ghislaine Gayan‐Ramirez
Abstract
Inconsistent histological alterations have been reported in children with cerebral palsy (CP) but whether they are present in very young and ambulant CP children and differ from those reported in old CP children is not known. This study highlighted for the first time that enhanced muscle fiber size variability and loss of capillaries are already present in very young CP children, even in the most ambulant ones, and these alterations seem to extend with age.
Topics & Concepts
Cerebral palsyTypically developingMedicinePediatricsPhysical medicine and rehabilitationPsychiatryAutismCerebral Palsy and Movement DisordersNeurogenetic and Muscular Disorders ResearchMuscle Physiology and Disorders