A Meta-Analysis on the Association of Colibactin-Producing <i>pks</i>+ <i>Escherichia coli</i> with the Development of Colorectal Cancer
Marcianne Elaine Gaab, Prim Olivette Lozano, Danica Ibañez, Korina Diane Manese, Fatima May Riego, Raphael Enrique Tiongco, Pia Marie Albano
Abstract
OBJECTIVE: Previous studies on the association between pks+Escherichia coli and colorectal cancer (CRC) demonstrated conflicting results. Hence, we performed a meta-analysis to obtain more precise estimates. METHODS: Related literature was obtained from PubMed, ScienceDirect, Google Scholar, and Cochrane Library. Data were then extracted, summarized, and subjected to analysis using Review Manager 5.4 by computing for the pooled odds ratios at the 95% confidence interval. RESULTS: Overall analysis showed that individuals carrying pks+E coli had a greater risk of developing CRC. Subgroup analysis further showed that individuals from Western countries carrying pks+E coli and individuals with pks+E coli in their tissue samples had increased risk of developing CRC. CONCLUSION: Results of this meta-analysis suggest that individuals with pks+E coli have a greater risk of developing CRC. However, more studies are needed to confirm our claims.