Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects
Zhendong Song, Linlin Lou, Guangjin Fan, Lu Liu, Ge Yang, He Liu, Albert S. C. Chan, Xiaolei Zhang, Xiao‐Feng Xiong
Topics & Concepts
KRASChemistryPyrimidineAllosteric regulationLinkerIn vivoIC50Cell growthPharmacologyLead compoundStereochemistryCancer researchIn vitroBiochemistryMutationBiologyEnzymeGeneticsComputer scienceOperating systemGeneProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingCancer therapeutics and mechanisms