Synthesis of benzo[<i>b</i>][1,5]diazocin-6(5<i>H</i>)-one derivatives <i>via</i> the Cu-catalysed oxidative cyclization of 2-aryl-1<i>H</i>-indoles with 1,1-enediamines
Yihua Chen, Jing Yang, Zihan Lu, Ke-Hua Zhao, Qiying Xie, Sheng‐Jiao Yan
Abstract
A novel protocol for the synthesis of highly functionalized benzo[ b ][1,5]diazocin-6(5 H )-one derivatives (BDCOs, 4 and 5) from 2-aryl-1 H -indoles and 1,1-enediamines was developed via a complex cascade of reactions.
Topics & Concepts
ChemistryRegioselectivityImineEnamineIntramolecular forceAnnulationArylMedicinal chemistryYield (engineering)TautomerTolueneCascade reactionCatalysisCombinatorial chemistryOrganic chemistryAlkylMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Biological EvaluationCyclopropane Reaction Mechanisms