Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation
Junli Huang, Zeli Ma, Zichao Yang, Zengzhu He, Jingna Bao, Xiaopeng Peng, Yao Liu, Ting Chen, Shumin Cai, Jianjun Chen, Zhenhua Zeng
Topics & Concepts
Bruton's tyrosine kinaseIbrutinibChemistryIn vivoNF-κBPharmacologyCancer researchSignal transductionImmunologyBiochemistryLeukemiaTyrosine kinaseMedicineChronic lymphocytic leukemiaBiologyBiotechnologyChronic Lymphocytic Leukemia ResearchProtein Degradation and InhibitorsMultiple Myeloma Research and Treatments