PEGylated lipid screening, composition optimization, and structure–activity relationship determination for lipid nanoparticle-mediated mRNA delivery
Lingyun Liu, Jae Heon Kim, Zhongyu Li, Mengwei Sun, Northen Trent, Jackie Tang, Emma Mcintosh, Shrirang Karve, Frank DeRosa
Abstract
observed with lower ionizable lipid and higher cholesterol fractions. Overall, balancing the ratios of all LNP components is critical for maximizing LNP functionality. This study presents a systematic evaluation and characterization of LNPs with different PEG-lipid moieties, deepens SAR understanding, and provides valuable guidelines for rationally designing more effective next-generation LNPs.
Topics & Concepts
NanoparticleComposition (language)Solid lipid nanoparticleChemistryNanotechnologyMaterials scienceLinguisticsPhilosophyRNA Interference and Gene DeliveryRNA and protein synthesis mechanisms