Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC)
Eliane Ebnoether, Laurent Müller
Abstract
Exosomes are nanovesicles part of a recently described intercellular communication system. Their properties seem promising as a biomarker in cancer research, where more sensitive monitoring and therapeutic applications are desperately needed. In the case of head and neck squamous cell carcinoma (HNSCC), overall survival often remains poor, although huge technological advancements in the treatment of this disease have been made. In the following review, diagnostic and therapeutic properties are highlighted and summarised. Impressive first results have been obtained but more research is needed to implement these innovative techniques into daily clinical routines.
Topics & Concepts
MicrovesiclesHead and neck squamous-cell carcinomaHead and neck cancerMedicineBiomarkerBasal cellCancerDiseaseHead and neckOncologyCancer researchBioinformaticsPathologyInternal medicinemicroRNABiologySurgeryBiochemistryGeneExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMicroRNA in disease regulation