Single-atom engineering of hemicyanine and its amphiphilic derivative for optimized near infrared phototheranostics
Shankun Yao, Yuncong Chen, Weizhong Ding, Fengwu Xu, Zhipeng Liu, Yaheng Li, Yanping Wu, Shumeng Li, Weijiang He, Zijian Guo
Abstract
, which easily formed nanoparticles with appealing features such as excellent photostability, effective prevention of unpleasant H-aggregation, fast/selective tumor accumulation and minimum dark toxicity. Solid tumor growth was significantly suppressed through combined photodynamic therapy (PDT) and photothermal therapy (PTT) guided by NIR fluorescence (NIRF) and photoacoustic (PA) imaging. This study not only presents the first example of selenium-substituted hemicyanine dyes, but also offers a reliable design strategy for the development of potent NIR phototheranostic agents with multi-mode imaging-guided combination therapeutic ability.