The role of FYCO1-dependent autophagy in lens fiber cell differentiation
Shahid Y. Khan, Muhammad Ali, Firoz Kabir, Chan Hyun Na, Michael Delannoy, Yinghong Ma, Caihong Qiu, M. Joseph Costello, J. Fielding Hejtmancik, S. Amer Riazuddin
Abstract
CC: congenital cataracts; DE: differentially expressed; ER: endoplasmic reticulum; FYCO1: FYVE and coiled-coil domain containing 1; hESC: human embryonic stem cell; KI: knock-in; OFZ: organelle-free zone; qRT-PCR: quantitative real-time PCR; PE: phosphatidylethanolamine; RNA-Seq: RNA sequencing; SD: standard deviation; sgRNA: single guide RNA; shRNA: shorthairpin RNA; TEM: transmission electron microscopy; WT: wild type.
Topics & Concepts
BiologyAutophagyCell biologyEndoplasmic reticulumTranscriptomeMolecular biologyGene expressionApoptosisGeneticsGeneConnexins and lens biologyVibrio bacteria research studiesAutophagy in Disease and Therapy