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Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration

Kaiting Yang, Wenbo Han, Xiaomin Jiang, András Piffkó, Jason Bugno, Chuanhui Han, Sirui Li, Hua Liang, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Jiaai Wang, Xiaona Huang, Jenny P.‐Y. Ting, Yang‐Xin Fu, Wenbin Lin, Ralph R. Weichselbaum

2022Nature Nanotechnology208 citationsDOI

Topics & Concepts

StingCancer researchMacrophageNanoparticleZincChemistryMaterials scienceMedicineNanotechnologyPhysicsBiochemistryIn vitroThermodynamicsOrganic chemistryinterferon and immune responsesInflammasome and immune disordersCancer Mechanisms and Therapy
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration | Litcius