Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Allylic Chlorides
Shuai Liu, Senlin Wang, Jie Wan, Shuang Peng, Jie-Rui Zhang, Hua-Jiao Ding, Bin Zhang, Hai‐Liang Ni, Peng Cao, Ping Hu, Bi‐Qin Wang, Bin Chen
Abstract
A nickel-catalyzed reductive cross-coupling of aziridines and allylic chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach to obtain β-allyl-substituted arylethylamines bearing various functional groups. The utility of this reaction was also demonstrated by scale-up preparation and diverse transformations, including the synthesis of Baclofen and several bioactive molecular motifs.
Topics & Concepts
Allylic rearrangementChemistryCatalysisCombinatorial chemistryNickelManganeseCoupling reactionFunctional groupCoupling (piping)Organic chemistryEngineeringMechanical engineeringPolymerCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions