Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads
Fan Pu, Nathaniel L. Elsen, Jon D. Williams
Abstract
Mass spectrometry (MS) detection can offer unmatched selectivity and sensitivity. The use of MS without chromatography greatly increases the throughput, making it suitable for high throughput screening. However, the trade-offs of direct MS detection need to be carefully evaluated along with the development of novel strategies to ensure successful implementation. In this review, we will discuss the pros and cons of chromatography-free MS and discuss some of the currently used and future technologies being investigated to enable high-throughput MS.
Topics & Concepts
ThroughputMass spectrometryComputer scienceHigh-throughput screeningChemistryChromatographyTelecommunicationsBiochemistryWirelessMass Spectrometry Techniques and ApplicationsAnalytical Chemistry and ChromatographyMetabolomics and Mass Spectrometry Studies