Ru-Catalyzed C–H Arylation of Acrylic Acids with Aryl Bromides
Florian Belitz, Ann‐Katrin Seitz, Jonas F. Goebel, Zhiyong Hu, Lukas J. Gooßen
Abstract
)-ratios of up to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity.
Topics & Concepts
ChemistryCatalysisArylStereoselectivityMedicinal chemistryLithium (medication)Surface modificationBase (topology)PalladiumStereochemistryCombinatorial chemistryOrganic chemistryAlkylMedicineMathematicsEndocrinologyPhysical chemistryMathematical analysisCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions